Not really. It’s good to have, but not a must. You can get a long way with DNS blocking which is more secure than MV2 content blocker extensions. Vanadium’s security is better than all other browsers on Android, especially on Google Pixels 8/Pro with MTE.
Refarding content blocking, privacy and security:
https://madaidans-insecurities.github.io/browser-tracking.html
Privacy and security are not the same
From what I have heard the consensus seems to be: just use uBlock Origin, I use it on medium mode (I used this as a guide: https://www.youtube.com/watch?v=2lisQQmWQkY).
The ublock origin documentation has great guides for medium/hard/easy mode