Things to think about are making it possible to navigate the site completely with nothing more then a keyboard, and making sure all images have an alt text to make sure no context is missed for people who cannot see them.
This is something I’ve been interested in for a long time, which was one of the reasons I originally suggested mkdocs-material, having said that though, some of these might be able to be fixed without too much difficulty.
By using a framework like that, we can spend more time on content, as opposed to developing the presentation.
Likely significant changes in this area will require upstream’s help.