I just use the ones recommended on the uBlock Origin wiki (I have it set to hard mode).
- All of uBO’s own filter lists
- EasyList
- EasyPrivacy
- Peter Lowe’s Ad and tracking server list
- Online Malicious URL Blocklist
I then also add the following to my rules:
* * 3p block
* * 3p-frame block
* * 3p-script block
* challenges.cloudflare.com * noop
However, that last bit does break a lot of modern sites.