With Rethink? Yes.
Use WireGuard in Advanced mode. Then add apps to be routed through it using the “Add / Remove” button in "Configure → Proxy → Setup WireGuard → (tap on the particular WireGuard profile)*.
If you’re on Android 12+, turn ON Configure → DNS → Split DNS if it isn’t, to make sure those apps setup to be routed through the WireGuard tunnel use WireGuard-provided DNS upstream.
The rest of the apps not setup to be routed through WireGuard should continue to use DNS setup in Configure → DNS.