I don’t know about Chameleon specifically, the general rule of thumb is a browser extension or spoofing your user-agent are subpar solutions compared withe either (1) Purpose built browsers (Mullvad, Tor) or (2) the FP protection built into mainstream browsers like Firefox or Brave. #1 being the preferred and strongest solution. I used to use an extension (canvasblocker) for basic protection, not I use Firefox’s built in FPP for that (which is enabled when you enable ETP strict mode).
As @exaCORE mentioned, the Arkenfox wiki (and github issues) are a great resource for info on fingerprinting protection. The Tor Project has some good content also.