Is this possible to do with a VPN or YogaDNS and Windows?

I mainly use Firefox and Brave on Windows 11. I have ProtonVPN and YogaDNS. Is it possible to set a tab within the browser to use a certain VPN location like London and another tab to Hong Kong?

With regards to YogaDNS, is it possible to do something where one tab or even the browser uses Control D and another tab or browser uses NextDNS?

With YogaDNS, is it possible to set an application in Windows to use a rule and use a certain DNS? What about a website?

If so, how?

Is Portmaster able to do any of this?

Thank you!